UNIFAC - Pesquisa Pré-Clínica e Clínica de Fármacos e Medicamentos

Linhas de pesquisa com interface com a REFARGEN

• Farmacologia Clínica
• Pesquisa Clínica
• Farmacogenética
• Desenvolvimento de Fármacos e Medicamentos
• Oncologia Experimental e Clínica
• Prospecção de Novas Moléculas com Potencial Antitumoral
• Toxicologia - Biomonitoramento

Publicações selecionadas

1. Gonçalves HS, Pontes MA, Bührer-Sékula S, Cruz R, Almeida PC, de Moraes ME, Penna GO. Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:74-8. PubMed PMID: 23283457.
2. Cerqueira JB, Gonzaga-Silva LF, da Silva FO, de Cerqueira JV, Oliveira RR, Moraes ME, Nascimento NR. Identification of mechanisms involved in the relaxation of rabbit cavernous smooth muscle by a new nitric oxide donor ruthenium compound. Int Braz J Urol. 2012 Sep-Oct;38(5):687-94. PubMed PMID: 23131510.
3. Silva D, Freitas ALP, Barros FCN, Lins KOAL, Alves APNN, ALENCAR N M N, Figueiredo IS, Moraes MO, Costa-Lotufo LV, Feitosa JPA, Maciel JS, Paula RCM. Polysaccharide isolated from Passiflora edulis: Characterization and Antitumor properties. Carbohydrate Polymers, v.87, p.139-145, 2012.
4. Moraes ME, Cunha GH, Bezerra MM, Fechine FV, Pontes AV, Andrade WS, Frota Bezerra FA, Moraes MO, Cavalcanti PP. Efficacy of the Mentha crispa in the treatment of women with Trichomonas vaginalis infection. Arch Gynecol Obstet. 2012 Jul;286(1):125-30. doi: 10.1007/s00404-012-2251-4. Epub 2012 Feb 21. PubMed PMID: 22350328.
5. Sousa AQ, Frutuoso MS, Moraes EA, Pearson RD, Pompeu MM. High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis. Clin Infect Dis. 2011 Oct;53(7):693-5. doi: 10.1093/cid/cir496. PubMed PMID: 21890773.
6. Araújo FY, de Oliveira GV, Gomes PX, Soares MA, Silva MI, Carvalho AF, Moraes MO, Moraes ME, Vasconcelos SM, Viana GS, de Sousa FC, Macêdo DS. Inhibition of ketamine-induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: possible involvement of an antioxidant effect. J Pharm Pharmacol. 2011 Aug; 63(8): 1103-10. doi: 10.1111/j.2042-7158.2011.01312.x. Epub 2011 Jun 11. PubMed PMID: 21718294.
7. Lobo PL, Fonteles CS, de Carvalho CB, do Nascimento DF, da Cruz Fonseca SG, Jamacaru FV, de Moraes ME. Dose-response evaluation of a novel essential oil against Mutans streptococci in vivo. Phytomedicine. 2011 May 15;18(7):551-6. doi: 10.1016/j.phymed.2010.10.018. Epub 2010 Nov 26. PubMed PMID: 21112195.
8. Cunha GH, Fechine FV, Santos LK, Pontes AV, Oliveira JC, Moraes MO, Bezerra FA, Moraes ME. Efficacy of the tincture of jalapa in the treatment of functional constipation: a double-blind, randomized, placebo-controlled study. Contemp Clin Trials. 2011 Mar;32(2):153-9. doi: 10.1016/j.cct.2010.10.011. Epub 2010 Oct 23. PubMed PMID: 20974290.
9. Paiva JC, Cabral IO, Soares BM, Sombra CM, Ferreira JR, Moraes MO, Cavalcanti BC, Pessoa C. Biomonitoring of rural workers exposed to a complex mixture of pesticides in the municipalities of Tianguá and Ubajara (Ceará state, Brazil): genotoxic and cytogenetic studies. Environ Mol Mutagen. 2011 Jul;52(6):492-501. doi: 10.1002/em.20647. Epub 2011 Mar 2. PubMed PMID: 21370288.
10. Vasconcellos MC, Moura DJ, Rosa RM, Machado MS, Guecheva TN, Villela I, Immich BF, Montenegro RC, Fonseca AM, Lemos TL, Moraes ME, Saffi J, Costa-Lotufo LV, Moraes MO, Henriques JA. Evaluation of the cytotoxic and antimutagenic effects of biflorin, an antitumor 1,4 o-naphthoquinone isolated from Capraria biflora L. Arch Toxicol. 2010 Oct;84(10):799-810. doi: 10.1007/s00204-010-0567-z. Epub 2010 Jun 23. PubMed PMID: 20571778.