Farmacogenética na População Brasileira

Linhas de pesquisa com interface com a REFARGEN

• Farmacogenômica populacional
• Farmacogenômica do câncer
• Farmacogenética da varfarina
• Farmacogenética do transplante renal
• Transleitura de códigos de parada em genes de interesse farmacológico ("farmacogenes") pelos antibióticos aminoglicosídicos.

Publicações selecionadas

1. Suarez-Kurtz G, Pena SD, Struchiner CJ, Hutz MH. Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin. Front Pharmacol. 2012;3:191. doi: 10.3389/fphar.2012.00191. Epub 2012 Nov 6. PubMed PMID: 23133420; PubMed Central PMCID: PMC3490152.
2. Suarez-Kurtz G, Pena SD, Hutz MH. Application of the F(ST) statistics to explore pharmacogenomic diversity in the Brazilian population. Pharmacogenomics. 2012 May;13(7):771-7. doi: 10.2217/pgs.12.39. PubMed PMID: 22594509.
3. Fuchshuber-Moraes M, Carvalho RS, Rimmbach C, Rosskopf D, Carvalho MA,Suarez-Kurtz G. Aminoglycoside-induced suppression of CYP2C19*3 premature stop codon. Pharmacogenet Genomics. 2011 Nov;21(11):694-700. doi: 10.1097/FPC.0b013e328349daba. PubMed PMID: 21934639.
4. Santoro A, Felipe CR, Tedesco-Silva H, Medina-Pestana JO, Struchiner CJ, Ojopi EB, Suarez-Kurtz G. Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients. Pharmacogenomics. 2011 Sep;12(9):1293-303. doi: 10.2217/pgs.11.70. Epub 2011 Aug 1. PubMed PMID: 21806386.
5. Vargens DD, Neves RR, Bulzico DA, Ojopi EB, Meirelles RM, Pessoa CN, Prado CM, Gonçalves PA, Leal VL, Suarez-Kurtz G. Association of the UGT1A1-53(TA)n polymorphism with L-thyroxine doses required for thyrotropin suppression in patients with differentiated thyroid cancer. Pharmacogenet Genomics. 2011 Jun;21(6):341-3. doi: 10.1097/FPC.0b013e3283448d19. PubMed PMID: 21317830.
6. Suarez-Kurtz G, Genro JP, de Moraes MO, Ojopi EB, Pena SD, Perini JA, Ribeiro-dos-Santos A, Romano-Silva MA, Santana I, Struchiner CJ. Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians. Pharmacogenomics J. 2012 Jun;12(3):267-76. doi: 10.1038/tpj.2010.89. Epub 2010 Dec 21. PubMed PMID: 21173785.
7. Suarez-Kurtz G, Perini JA, Silva-Assunção E, Struchiner CJ. Relative contribution of VKORC1, CYP2C9, and INR response to warfarin stable dose. Blood. 2009 Apr 23;113(17):4125-6. doi: 10.1182/blood-2009-01-200600. PubMed PMID: 19389892.
8. Estrela Rde C, Ribeiro FS, Barroso PF, Tuyama M, Gregório SP, Dias-Neto E, Struchiner CJ, Suarez-Kurtz G. ABCB1 polymorphisms and the concentrations of lopinavir and ritonavir in blood, semen and saliva of HIV-infected men under antiretroviral therapy. Pharmacogenomics. 2009 Feb;10(2):311-8. doi: 10.2217/14622416.10.2.311. PubMed PMID: 19207033.
9. Suarez-Kurtz, G. (editor) Pharmacogenomics in Admixed Populations, Landes Bioscience, Austin, TX, USA, 2007.
10. Vianna-Jorge R, Perini JA, Rondinelli E, Suarez-Kurtz G. CYP2C9 genotypes and the pharmacokinetics of tenoxicam in Brazilians. Clin Pharmacol Ther. 2004 Jul;76(1):18-26. PubMed PMID: 15229460.